Targeting oncogene dependence and resistance
نویسندگان
چکیده
منابع مشابه
Targeting of non-oncogene addiction
pathways control all phases of tumor development and are critical in cancer therapy as they are largely responsible for the ability of tumor cells to survive or die in response to chemotherapy and radiotherapy. The p38 MAPK signaling pathway is one of the routes that cells use extensively to interpret extracellular signals and orchestrate appropriate responses. This pathway was originally chara...
متن کاملOncogene interference through targeting of chromatin regulators
The chromatin regulatory machinery is often exploited during tumorigenesis. For example, many of the central transcription factors in cancer biology (such as p53 and Myc) utilize chromatin regulators (CRs) as coactivators or corepressors to regulate their downstream target genes. Moreover, somatic mutation of CR-encoding genes is a common driver mechanism seen in many cancer types. Hence, CRs o...
متن کاملTargeting Resistance
Wrestling with cancer can be frustrating. Despite the progress in developing therapies that can effectively control tumor growth, the devil almost always strikes back with resistance. Even for the recent excitement in using immunotherapy to achieve unprecedented success in some cancer patients, resistance has been seen in clinical settings and is under active investigation (Restifo et al., 2016...
متن کاملTargeting MCT-1 oncogene inhibits Shc pathway and xenograft tumorigenicity
Overexpression of Shc adaptor proteins is associated with mitogenesis, carcinogenesis and metastasis. Multiple copies in T-cell malignancy 1 (MCT-1) oncoprotein promotes cell proliferation, survival and tumorigenic effects. Our current data show that MCT-1 is a novel regulator of Shc-Ras-MEK-ERK signaling and MCT-1 is significantly co-activated with Shc gene in human carcinomas. The knockdown o...
متن کاملTargeting Translation Dependence in Cancer
A challenge in cancer therapy is to selectively target activities that are essential for survival of malignant cells while sparing normal cells. Translational control represents a potential anti-neoplastic target because it is exerted by major signaling pathways that are often usurped in cancers. Herein we describe approaches being developed that target eukaryotic initiation factor (eIF) 4F, a ...
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ژورنال
عنوان ژورنال: Cancer Cell
سال: 2003
ISSN: 1535-6108
DOI: 10.1016/s1535-6108(03)00115-6